Elevated serum neopterin levels in children with functional constipation: association with systemic proinflammatory cytokines

Cirali C., Ulusoy E., KÜME T., ARSLAN N.

WORLD JOURNAL OF PEDIATRICS, vol.14, no.5, pp.448-453, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.1007/s12519-018-0144-8
  • Journal Name: WORLD JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.448-453
  • Keywords: Children, Constipation, Cytokine, Inflammation, Neopterin, IRRITABLE-BOWEL-SYNDROME, LOW-GRADE INFLAMMATION, URINARY NEOPTERIN, DISEASE, MARKER, CANCER, CALPROTECTIN, BIOMARKERS, RISK
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background Functional constipation is a clinical problem with an incompletely understood etiology. Functional bowel diseases have been shown to be related to inflammation in many studies in adults. In this study, we aimed to evaluate leukocytes, C-reactive protein, proinflammatory and anti-inflammatory cytokines, and neopterin levels in children with functional constipation.