Multicentric reticulohistiocytosis

Kocanaogullari H., Ozsan H., Oksel F., Ozturk G., Kandiloglu G., Ustun E., ...More

CLINICAL RHEUMATOLOGY, vol.15, no.1, pp.62-66, 1996 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 1996
  • Doi Number: 10.1007/bf02231688
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.62-66
  • Keywords: multicentric reticulohistiocytosis, destructive polyarthritis, mucocutaneous eruption, azathioprine, ARTHRITIS
  • Dokuz Eylül University Affiliated: Yes


We describe a 42-year-old man with a five-year history of arthritis mutilans-like destructive joint changes and with a one-year history of nodules on the fingers, ears, oral mucosa, pharynx, larynx, vocal cords, some being ulcerated and haemorrhagic. He was diagnosed as having rheumatoid arthritis; however, biopsies from the nodules an the oral mucosa and ear revealed multicentric reticulohistiocytosis, The large nodule over the olecranon process, simulating a rheumatoid nodule but diagnosed as multicentric reticulohistiocytosis with biopsy; ulcerated and haemorrhagic nodules on the oral mucosa; and rapidly progressive joint destructions make our case interesting.