Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities


DOĞAN Ö., POLAT ÇAKIR S., Beksultanova N., ALTANLAR N., Simsek D., KARABIYIK H.

TETRAHEDRON-ASYMMETRY, cilt.28, sa.2, ss.324-329, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.tetasy.2017.01.003
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.324-329
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

A new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity. (C) 2017 Elsevier Ltd. All rights reserved.