Flufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the rat

Bal R., Ustundag Y., Bulut F., Demir C. F., Bal A.

ARCHIVES OF MEDICAL SCIENCE, vol.12, no.1, pp.208-215, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.5114/aoms.2016.57597
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.208-215
  • Keywords: tinnitus, salicylate, flufenamic acid, TRPM2, experimental, rat, DORSAL COCHLEAR NUCLEUS, NONSTEROIDAL ANTIINFLAMMATORY DRUG, INFERIOR COLLICULUS, GABA(A) RECEPTORS, HEARING-LOSS, NEURONS, CURRENTS, CHANNEL, MODEL, TRPM2
  • Dokuz Eylül University Affiliated: No

Abstract

Introduction: Tinnitus is defined as a phantom auditory sensation, the perception of sound in the absence of external acoustic stimulation. Given that flufenamic acid (FFA) blocks TRPM2 cation channels, resulting in reduced neuronal excitability, we aimed to investigate whether FFA suppresses the behavioral manifestation of sodium salicylate (SSA)-induced tinnitus in rats.