Flufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the rat

Bal R., Ustundag Y., Bulut F., Demir C. F., Bal A.

ARCHIVES OF MEDICAL SCIENCE, cilt.12, sa.1, ss.208-215, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5114/aoms.2016.57597
  • Dergi Adı: ARCHIVES OF MEDICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.208-215
  • Anahtar Kelimeler: tinnitus, salicylate, flufenamic acid, TRPM2, experimental, rat, DORSAL COCHLEAR NUCLEUS, NONSTEROIDAL ANTIINFLAMMATORY DRUG, INFERIOR COLLICULUS, GABA(A) RECEPTORS, HEARING-LOSS, NEURONS, CURRENTS, CHANNEL, MODEL, TRPM2
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Introduction: Tinnitus is defined as a phantom auditory sensation, the perception of sound in the absence of external acoustic stimulation. Given that flufenamic acid (FFA) blocks TRPM2 cation channels, resulting in reduced neuronal excitability, we aimed to investigate whether FFA suppresses the behavioral manifestation of sodium salicylate (SSA)-induced tinnitus in rats.