The comparative effects of total hepatic vascular isolation techniques performed at different durations in rat

Kaya H., Karademir S., Tuncel P., Astarcioglu H., SAĞOL Ö., Astarcloglu I.

JOURNAL OF SURGICAL RESEARCH, vol.145, no.2, pp.223-228, 2008 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 145 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1016/j.jss.2007.04.024
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.223-228
  • Keywords: hepatic vascular exclusion, supraceliac aortic clamping, celio-mesenteric arterial occllusion, reperfusion injury, survival
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background. Total hepatic vascular exclusion (THVE) leads to massive venous congestion below the level of diaphragm and may promote undesirable hemodynamic disturbances in some patients. Supraceliac aortic clamping during THVE may achieve hemodynamic stability at the price of arterial ischemia. However, the parenchymal injury of venous congestion has been a greater concern than of arterial ischemia in various settings. We hypothesized that supraceliac aortic occlusion during THVE may attenuate the reperfusion injury and improve the outcome that would be acquired after THVE alone.