Effects of Serelaxin in Patients with Acute Heart Failure

Metra, Marco; Teerlink, John; Cotter, Gad; Davison, Beth; Felker, G.; Filippatos, Gerasimos; Greenberg, Barry; Pang, Peter; Ponikowski, Piotr; Voors, Adriaan; Adams, Kirkwood; Anker, Stefan; Arias-Mendoza, Alexandra; Avendano, Patricio; Bacal, Fernando; Boehm, Michael; Bortman, Guillermo; Cleland, John; Cohen-Solal, Alain; Crespo-Leiro, Maria; Dorobantu, Maria; Echeverria, Luis; Ferrari, Roberto; Goland, Sorel; Goncalvesova, Eva; Goudev, Assen; Kober, Lars; Lema-Osores, Juan; Levy, Phillip; Mcdonald, Kenneth; Manga, Pravin; Merkely, Bela; Mueller, Christian; Pieske, Burkert; Silva-Cardoso, Jose; Spinar, Jindrich; Squire, Iain; Stepinska, Janina; Van Mieghem, Walter; Von Lewinski, Dirk; Wikstrom, Gerhard; Yılmaz, MEHMET; Hagner, Nicole; Holbro, Thomas; Hua, Tsushung; Sabarwal, Shalini; Severin, Thomas; Szecsody, Peter; Gimpelewicz, Claudio

doi:10.1056/nejmoa1801291

Effects of Serelaxin in Patients with Acute Heart Failure

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Metra M., Teerlink J. R., Cotter G., Davison B. A., Felker G. M., Filippatos G., ...More

NEW ENGLAND JOURNAL OF MEDICINE, vol.381, no.8, pp.716-726, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 381 Issue: 8
Publication Date: 2019
Doi Number: 10.1056/nejmoa1801291
Journal Name: NEW ENGLAND JOURNAL OF MEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.716-726
Dokuz Eylül University Affiliated: Yes

Abstract

BackgroundSerelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that contributes to cardiovascular and renal adaptations during pregnancy. Previous studies have suggested that treatment with serelaxin may result in relief of symptoms and in better outcomes in patients with acute heart failure.