A possible connection between tumor necrosis factor alpha and adropin levels in polycystic ovary syndrome.

Kume T., Calan M., Yilmaz O., Kocabas G. U., Yesil P., Temur M., ...Daha Fazla

Journal of endocrinological investigation, cilt.39, sa.7, ss.747-54, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 7
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s40618-016-0453-5
  • Dergi Adı: Journal of endocrinological investigation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.747-54
  • Anahtar Kelimeler: Polycystic ovary syndrome, Adropin, Tumor necrosis factor-alpha, Insulin resistance, Cytokine, TNF-ALPHA, INSULIN-RESISTANCE, DIABETES-MELLITUS, DISEASE, OBESITY, LEPTIN, ADIPOCYTES, EXPRESSION, SECRETION, WOMEN
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Context Adropin is a peptide hormone implicated in the regulation of insulin sensitivity and energy homeostasis. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disease associated with insulin resistance. It has been demonstrated that various inflammatory markers increased in PCOS including TNF-alpha. TNF-alpha regulates the secretion of certain peptides which play a crucial role in glucose and lipid homeostasis. There is also some evidence of a link between TNF-alpha and adropin.