A possible connection between tumor necrosis factor alpha and adropin levels in polycystic ovary syndrome.


Kume T., Calan M., Yilmaz O., Kocabas G. U., Yesil P., Temur M., ...More

Journal of endocrinological investigation, vol.39, no.7, pp.747-54, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 7
  • Publication Date: 2016
  • Doi Number: 10.1007/s40618-016-0453-5
  • Journal Name: Journal of endocrinological investigation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.747-54
  • Keywords: Polycystic ovary syndrome, Adropin, Tumor necrosis factor-alpha, Insulin resistance, Cytokine, TNF-ALPHA, INSULIN-RESISTANCE, DIABETES-MELLITUS, DISEASE, OBESITY, LEPTIN, ADIPOCYTES, EXPRESSION, SECRETION, WOMEN
  • Dokuz Eylül University Affiliated: Yes

Abstract

Context Adropin is a peptide hormone implicated in the regulation of insulin sensitivity and energy homeostasis. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disease associated with insulin resistance. It has been demonstrated that various inflammatory markers increased in PCOS including TNF-alpha. TNF-alpha regulates the secretion of certain peptides which play a crucial role in glucose and lipid homeostasis. There is also some evidence of a link between TNF-alpha and adropin.