Association between serum macrophage colony-stimulating factor levels and monocyte and thrombocyte counts in healthy, hypoxic, and septic term neonates


Oren H., Duman N., Abacioglu H., ÖZKAN H., Irken G.

PEDIATRICS, vol.108, no.2, pp.329-332, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 108 Issue: 2
  • Publication Date: 2001
  • Doi Number: 10.1542/peds.108.2.329
  • Journal Name: PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.329-332
  • Keywords: macrophage-colony-stimulating factor, thrombocytopenia, monocyte, sepsis, neonate, HEMATOPOIETIC GROWTH-FACTORS, TUMOR NECROSIS FACTOR, INFLAMMATORY RESPONSE SYNDROME, FACTOR CSF-1, FACTOR-I, FACTOR EXPRESSION, CORD-BLOOD, GM-CSF, GRANULOCYTE, INTERFERON
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective. Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor that mainly stimulates the growth, differentiation, and proliferation of cells of the monocyte-macrophage lineage. There are only limited numbers of studies about M-CSF levels in neonates, but high levels of serum M-CSF have been reported in septic and some thrombocytopenic adult patients. In this study, we investigated the serum M-CSF levels in healthy, septic, and hypoxic term neonates on the first day of life and examined the relationship of serum M-CSF levels and circulating monocyte and thrombocyte counts in these newborn infants.