Bone Cancer Metastatic Model on Pla Scaffold with Breast Cancer Cell Lines

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Bekcioğlu Ö., Aydın M., Hüsemoğlu B., Aktaş S., Havıtcıoğlu H., Olgun H. N.

Turk J Hip Surg, cilt.4, sa.3, ss.209-213, 2024 (Hakemli Dergi)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 4 Sayı: 3
• Basım Tarihi: 2024
• Doi Numarası: 10.5505/tjhs.2024.09797
• Dergi Adı: Turk J Hip Surg
• Derginin Tarandığı İndeksler: Other Indexes
• Sayfa Sayıları: ss.209-213
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Breast cancer (BC) represents the most frequent cancer case in women (29%), with a high mortality rate. Bone metastasis occurs in around 20–50% of the cases,

and despite the advances in BC research, the interactions between tumor cells and the metastatic microenvironment remain poorly understood. In vitro 3D models

gained a considerable interest in cancer research due to their reproducibility, 3D spatial cues and associated low costs, compared to in vivo and 2D in vitro models.

In this study, we investigated the suitability of a poly-lactic acid (PLA) foam as a 3D in vitro model to study and compare the 3D structure of three different breast

cancer cell lines (MCF-7, 4T1, MDA-MB-231). PLA foam open porosity (>70%) appeared to be suitable for mimicking the trabecular bone structure (hexagonal

structure). The PLA foam showed good mechanical properties under cyclic compression (E = 69–109 kPa), even lower than human trabecular bone. This study

presents a new 3D cell culture model for metastatic BC for researchers to construct in vitro bone morphology.

Keywords: Metastatıc model, breast cancer, 3d modeL

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