The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation

ALOTAİBİ H., Tuzlakoglu-Ozturk M., TAZEBAY U. H.

MOLECULAR IMAGING AND RADIONUCLIDE THERAPY, cilt.26, ss.92-101, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 26
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/2017.26.suppl.11
  • Dergi Adı: MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.92-101
  • Anahtar Kelimeler: Iodide, thyroid, Na+/I- symporter, radiotherapy, thyroid cancer, gene regulation, SODIUM-IODIDE SYMPORTER, MESSENGER-RIBONUCLEIC-ACID, SODIUM/IODIDE-SYMPORTER, RETINOIC ACID, GENE-EXPRESSION, REDIFFERENTIATION THERAPY, MAMMARY-GLAND, RADIOIODIDE UPTAKE, STIMULATING HORMONE, BINDING-PROTEINS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Iodide (I-) is an essential constituent of the thyroid hormones triiodothyronine (T-3) and thyroxine (T-4), and the iodide concentrating mechanism of the thyroid gland is essential for the synthesis of these hormones. In addition, differential uptake of iodine isotopes (radioiodine) is a key modality for the diagnosis and therapy of thyroid cancer. The sodium dependent iodide transport activity of the thyroid gland is mainly attributed to the functional expression of the Na+/I- Symporter (NIS) localized at the basolateral membrane of thyrocytes. In this paper, we review and summarize current data on molecular characterization, on structure and function of NIS protein, as well as on the transcriptional regulation of NIS encoding gene in the thyroid gland. We also propose that a better and more precise understanding of NIS gene regulation at the molecular level in both healthy and malignant thyroid cells may lead to the identification of small molecule candidates. These could then be translated into clinical practice for better induction and more effective modulation of radioiodine uptake in dedifferentiated thyroid cancer cells and in their distant metastatic lesions.