A network meta-analysis on comparative efficacy and all-cause discontinuation of antimanic treatments in acute bipolar mania


Yildiz A., Nikodem M., Vieta E., Correll C. U., Baldessarini R. J.

PSYCHOLOGICAL MEDICINE, vol.45, no.2, pp.299-317, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1017/s0033291714001305
  • Journal Name: PSYCHOLOGICAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.299-317
  • Keywords: All-cause discontinuations, antimanic, bipolar, mania, multiple treatments meta-analysis, DOUBLE-BLIND, MULTIPLE-TREATMENTS, AFFECTIVE-DISORDERS, I DISORDER, LITHIUM, VALPROATE, CARBAMAZEPINE, HALOPERIDOL, CARIPRAZINE, 12-WEEK
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background. Evidence synthesis methods enabling direct and indirect comparisons over the entire set of relevant clinical data produce quantitative point estimates for the treatments contrasts between competing interventions, and provide a hierarchical rank ordering between them. We aimed to provide evidence-based guidance on the efficacy and all-cause discontinuation of antimanic treatments.