Clinical Response to Adjunctive Pegylated Interferon Alpha-2a Treatment in Disseminated Mycobacterial Infection in Children with Complete IFNGR1 Deficiency: A Case Report

ATAKUL G., ATAY Ö., KARAOĞLU ASRAK H., ERBAŞ İ. C., ASİLSOY S., BELET N., ...More

JOURNAL OF PEDIATRIC INFECTIOUS DISEASES, vol.17, no.05, pp.264-268, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 05
  • Publication Date: 2022
  • Doi Number: 10.1055/s-0042-1749646
  • Journal Name: JOURNAL OF PEDIATRIC INFECTIOUS DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database
  • Page Numbers: pp.264-268
  • Keywords: interferon gamma receptor 1 (IFNGR1), interferon alpha-2a, Mendelian susceptibility to mycobacterial disease, child
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective Interferon gamma receptor 1 (IFNGR1) deficiency is a primary immunodeficiency that causes systemic infections with weakly virulent nontuberculous mycobacteria, which are very difficult to control with combined antimycobacterial agents.