Research Information System
15. Ulusal Meme Hastalıkları Kongresi, Antalya, Turkey, 17 - 20 October 2019, pp.32-33, (Summary Text)
SS101-Does Microscopic Epidermal Ulseration Present Effect The Breast Cancer Stage?
Merih Güray Durak1
, Sümeyye Ekmekçi2
, Zümre Arıcan Alıcıkuş3
, Volkan Semiz3
, Işıl Somali4
, Ali İbrahim Sevinç5
,
İlknur Bilkay Görken3
1
Department of Pathology, Dokuz Eylul University School of Medicine, İzmir, Turkey
2
Department of Pathology, İzmir University ofHealth Sciences, Tepecik Training and Research Hospital, İzmir, Turkey
3
Department of Radiation Oncology, Dokuz Eylül University School of Medicine, İzmir, Turkey
4
Department of Internal Medicine, Dokuz Eylül University School of Medicine, İzmir, Turkey
5
Department of General Surgery, Dokuz Eylül University School of Medicine, İzmir, Turkey
Objective: Invasive breast carcinoma is the most common cancer in women. Accurate staging after diagnosis is very important in predicting
prognosis and evaluating treatment response. According to the TNM classification of breast cancer, tumors that show direct extension to the
chest wall and/or skin regardless of size are considered pT4. However, to diagnose pT4 breast cancer, skin invasion must be accompanied by
ulceration or macroscopically defined skin nodules. Only the presence of dermal invasion is not sufficient for the pT4 stage. In this study, we
aimed to evaluate the effect of epidermal ulceration on prognosis in breast cancer patients with microscopic dermal invasion.
Materials and Methods: The study included 193 patients diagnosed with breast cancer in our hospital between 2002 and 2016 who had
microscopic dermal invasion. Preparations were re-evaluated for tumor type, histological grade, tumor size, lymphovascular invasion, receptor
and HER2 status as well as the presence of epidermal ulceration. Local recurrence and overall survival data of the patients whose treatment was
continued in our hospital after diagnosis and followed up were obtained and statistical analysis was performed using SPSS 15.0.
Results: 184 patients were female and their ages ranged between 26-91 (mean 59.5). Microscopic epidermal ulceration was detected in 17.6%
of the patients. The most common tumor type was invasive ductal carcinoma (45.8%) and most of the patients (62.4%) were grade 2. The
presence of microscopic epidermal ulceration was significantly associated with blood vessel invasion (p=0.035). Distant metastasis was detected
in 76.2% of the patients who had epidermal ulceration in pathology specimens (p=0.006). In patients with a mean follow-up of 76.7 months,
distant metastasis was significantly associated with survival (p<0.001). The presence of epidermal ulceration did not show a significant relationS32 ship with survival.
Eur J Breast Health 2019; Supplement(1): S1-S39
Conclusion: Although the presence of microscopic epidermal ulceration is significantly associated with blood vessel invasion and distant metastasis, it is not related to overall survival. However, in breast cancer patients with microscopic dermal invasion accompanied by epidermal
ulceration, chemotherapy can be planned more effectively for distant metastasis.
Keywords: Breast cancer, dermal invasion, epidermal ulceration