Alternative factors in differential diagnosis of infantile fibrosarcoma

Aktaş S., Diniz G., Ortaç R., YÖRÜKOĞLU K.

Turkish Journal of Cancer, vol.34, no.4, pp.150-155, 2004 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 4
  • Publication Date: 2004
  • Journal Name: Turkish Journal of Cancer
  • Journal Indexes: Scopus, Academic Search Premier
  • Page Numbers: pp.150-155
  • Keywords: Angiogenesis, Fibrous tumors, Ki-67, Mitosis, nm23
  • Dokuz Eylül University Affiliated: Yes


The aim of this study was to determine the role of nm23 expression, percentage of Ki-67 labelling, vascularisation, mitosis and histologic features such as pattern, cellularity and density of inflammatory cell infiltrate in differential diagnosis of fibrous tumors. Specimens of 16 fibrous tumor cases were studied: 6 infantile fibrosarcoma (IFS), 3 adult fibrosarcoma (AFS) and 7 benign fibrous proliferations. All findings were examined and correlated statistically. In conclusion, number of inflammatory cells, histologic pattern and age of the patient are helpful in differential diagnosis of IFS and AFS.