Molecular Mechanisms of Protective Effect of Resveratrol Against Cisplatinium Induced Ototoxicity

OLGUN Y., ALTUN Z. S., Aktas S., Ercetin P., KIRKIM G., KİRAY M., ...More

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, vol.9, no.2, pp.145-152, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2013
  • Journal Name: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.145-152
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Cisplatinium is one of the most widely used anticancer drugs. Side effects such as ototoxicity, nephrotoxicity and neurotoxicity limit to reach high doses. It mainly induces apoptosis in auditory sensory cells. Resveratrol is a polyphenol mostly found in grape skin and seed. It has anti-oxidant, neuroprotective and dose dependent antiapoptotic properties. It was claimed to protect side effects of some chemotherapeutic agents. In this study possible otoprotective effects of resveratrol were studied in House Ear Institute-Organ of Corti 1 cell line.