Effects of Biologic Therapies for Cutaneous Inflammatory Diseases in HIV-Infected Individuals: Reliable or Not?

AKARSU S., Avci C.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.2, sa.3, ss.61-67, 2018 (ESCI, TRDizin) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 2 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.30621/jbachs.2018.357
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.61-67
  • Anahtar Kelimeler: human immunodeficiency virus, cutaneous inflammatory diseases, psoriasis and psoriatic arthritis, hidradenitis suppurativa, pemphigus vulgaris, biologic therapy
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Patients with cutaneous inflammatory diseases often present with more aggressive and refractory clinical course in the presence of accompanying human immunodeficiency virus (HIV) infection. Therefore, biologic therapies may be needed to improve outcomes of these patients. The use of biologic agents in HIV positive patients is conflicting because such treatment can lead to increase the risk of infection and malignancy in already immunocompromised patients. On the other hand, some researchers have recommended that HIV management should also include the blockade of tumour necrosis factor-alpha (TNF-alpha). We discuss the reliability and effectiveness of biologic therapies for patients with cutaneous inflammatory diseases and accompanying HIV infection.