Is mannitol effective against platelet-activating factor (PAF)-induced liver damage in obstructive jaundice?

Coker A., Coker I., Huseyinov A., SÖKMEN S., Karademir S.

HEPATO-GASTROENTEROLOGY, vol.48, no.40, pp.1134-1137, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 40
  • Publication Date: 2001
  • Journal Name: HEPATO-GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1134-1137
  • Keywords: PAF, jaundice, liver, mannitol, FUTURE CLINICAL IMPLICATIONS, HEPATOCYTE MEMBRANE, PAF-ACETYLHYDROLASE, RAT HEPATOCYTES, ANTAGONISTS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background/Aims: Platelet-activating factor, is a unique phospholipid with a broad range of biological activities that may be relevant in the development of inflammatory reactions. Platelet-activating factor has been suspected to play an important role in liver pathophysiology. The cultured Kupffer and endothelial cells produce and release platelet-activating factor in order to facilitate communication between hepatic sinusoidal and parenchymal cells. In this study, in the experimental jaundice model, platelet-activating factor levels were measured in liver tissue and plasma and the possible effects of mannitol on this mediator were assessed.