Is mannitol effective against platelet-activating factor (PAF)-induced liver damage in obstructive jaundice?

Coker A., Coker I., Huseyinov A., SÖKMEN S., Karademir S.

HEPATO-GASTROENTEROLOGY, cilt.48, sa.40, ss.1134-1137, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 40
  • Basım Tarihi: 2001
  • Dergi Adı: HEPATO-GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1134-1137
  • Anahtar Kelimeler: PAF, jaundice, liver, mannitol, FUTURE CLINICAL IMPLICATIONS, HEPATOCYTE MEMBRANE, PAF-ACETYLHYDROLASE, RAT HEPATOCYTES, ANTAGONISTS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/Aims: Platelet-activating factor, is a unique phospholipid with a broad range of biological activities that may be relevant in the development of inflammatory reactions. Platelet-activating factor has been suspected to play an important role in liver pathophysiology. The cultured Kupffer and endothelial cells produce and release platelet-activating factor in order to facilitate communication between hepatic sinusoidal and parenchymal cells. In this study, in the experimental jaundice model, platelet-activating factor levels were measured in liver tissue and plasma and the possible effects of mannitol on this mediator were assessed.