Is mannitol effective against platelet-activating factor (PAF)-induced liver damage in obstructive jaundice?
HEPATO-GASTROENTEROLOGY, cilt.48, sa.40, ss.1134-1137, 2001 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 40
- Basım Tarihi: 2001
- Dergi Adı: HEPATO-GASTROENTEROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1134-1137
- Anahtar Kelimeler: PAF, jaundice, liver, mannitol
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Background/Aims: Platelet-activating factor, is a unique phospholipid with a broad range of biological activities that may be relevant in the development of inflammatory reactions. Platelet-activating factor has been suspected to play an important role in liver pathophysiology. The cultured Kupffer and endothelial cells produce and release platelet-activating factor in order to facilitate communication between hepatic sinusoidal and parenchymal cells. In this study, in the experimental jaundice model, platelet-activating factor levels were measured in liver tissue and plasma and the possible effects of mannitol on this mediator were assessed.