Resveratrol ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesions through effects on the epithelium

Sozmen, Sule; KARAMAN, MERAL; CİLAKER MIÇILI, SERAP; IŞIK, SAKİNE; Ayyildiz, Zeynep; BAĞRIYANIK, HÜSNÜ; UZUNER, NEVİN; KARAMAN, ÖZKAN

doi:10.7717/peerj.1889

Resveratrol ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesions through effects on the epithelium

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Sozmen S. C., KARAMAN M., CİLAKER MIÇILI S., IŞIK S., Ayyildiz Z. A., BAĞRIYANIK H. A., ...More

PEERJ, vol.4, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 4
Publication Date: 2016
Doi Number: 10.7717/peerj.1889
Journal Name: PEERJ
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: Treatment, Atopic dermatitis, Mice, Resveratrol, NF-KAPPA-B, KERATINOCYTE APOPTOSIS, ECZEMATOUS DERMATITIS, THERAPEUTIC TARGET, DOWN-REGULATION, SKIN BARRIER, MOUSE MODEL, IFN-GAMMA, INFLAMMATION, CELLS
Dokuz Eylül University Affiliated: Yes

Abstract

Background. Resveratrol is a natural polyphenol that exhibits anti-inflammatory effects. The aim of this study was to investigate the effects of resveratrol treatment on epithelium-derived cytokines and epithelial apoptosis in a murine model of atopic dermatitis-like lesions.