Kit expression in spindle cell rhabdomyosarcoma can possibly create a different approach for its tumorigenesis and therapy

Diniz, Gulden; Aktas, SAFİYE; Ortac, Ragip; Tunakan, Mine; Unlu, Ismet; Vergin, Canan

doi:10.1016/j.prp.2006.04.007

Kit expression in spindle cell rhabdomyosarcoma can possibly create a different approach for its tumorigenesis and therapy

Diniz G., Aktas S., Ortac R., Tunakan M., Unlu I., Vergin C.

PATHOLOGY RESEARCH AND PRACTICE, cilt.202, sa.9, ss.671-677, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 202 Sayı: 9
Basım Tarihi: 2006
Doi Numarası: 10.1016/j.prp.2006.04.007
Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.671-677
Anahtar Kelimeler: KIT expression, STI-571, spindle cell rhabdomyosarcoma, tumorigenesis
Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

The use of a relatively nontoxic tyrosine kinase receptor inhibitor, imatimb mesylate (IM) (STI-571), has increasingly become a valuable therapeutic alternative in some KIT (CD117)-overexpressing neoplasms potentially because of the presence of KIT-activating mutations. As the treatment eligibility for this drug hinges on CD117 expression. KIT immunostaining has recently been widely examined in various different tumors.