Intrathecal IgM index correlates with a severe disease course in multiple sclerosis: Clinical and MRI results

ÖZAKBAŞ S., Cinar B. P., KAYA ÖZÇELİK P., Baser H., Kosehasanogullari G.

CLINICAL NEUROLOGY AND NEUROSURGERY, cilt.160, ss.27-29, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 160
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.clineuro.2017.05.026
  • Dergi Adı: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.27-29
  • Anahtar Kelimeler: Multiple sclerosis, Cerebrospinal fluid, Immunoglobulin M
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objectives: Intrathecally synthesized IgM can be seen not only in the cerebrospinal fluid (CSF) in infectious and inflammatory diseases of the central nervous system, but also in that of patients with multiple sclerosis (MS). Intrathecal IgM synthesis in MS seems to be correlated with an unfavorable disease course. In one cross-sectional study, intrathecal synthesis of IgM (IgM index) was found to be correlated with cranial magnetic resonance imaging (MRI) parameters. The purpose of this study was to determine the possible relationship between the IgM index and MRI and clinical parameters.