Intrathecal IgM index correlates with a severe disease course in multiple sclerosis: Clinical and MRI results

ÖZAKBAŞ S., Cinar B. P., KAYA ÖZÇELİK P., Baser H., Kosehasanogullari G.

CLINICAL NEUROLOGY AND NEUROSURGERY, vol.160, pp.27-29, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 160
  • Publication Date: 2017
  • Doi Number: 10.1016/j.clineuro.2017.05.026
  • Journal Name: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.27-29
  • Keywords: Multiple sclerosis, Cerebrospinal fluid, Immunoglobulin M
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: Intrathecally synthesized IgM can be seen not only in the cerebrospinal fluid (CSF) in infectious and inflammatory diseases of the central nervous system, but also in that of patients with multiple sclerosis (MS). Intrathecal IgM synthesis in MS seems to be correlated with an unfavorable disease course. In one cross-sectional study, intrathecal synthesis of IgM (IgM index) was found to be correlated with cranial magnetic resonance imaging (MRI) parameters. The purpose of this study was to determine the possible relationship between the IgM index and MRI and clinical parameters.