Investigation of in vitro effects of estrogens and selective estrogen receptor modulators (serms) on Trichomonas vaginalis
AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, cilt.6, sa.43, ss.7078-7083, 2012 (Hakemli Dergi)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 43
- Basım Tarihi: 2012
- Doi Numarası: 10.5897/ajmr12.920
- Dergi Adı: AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH
- Derginin Tarandığı İndeksler: CAB Abstracts, Veterinary Science Database
- Sayfa Sayıları: ss.7078-7083
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
The aim of this study was to investigate if there is a relationship between the hormones and Trichomonas vaginalis growth. A strain of T. vaginalis, was incubated and cultivated to compare the in vitro effects of 17β-Estradiol, Estriol, Raloxifene, Tamoxifen on T. vaginalis trophozoites in terms of different concentrations. High concentrations of 17β-Estradiol and Estriol (20 ng/ml), and Tamoxifen and Raloxifene (100 ng/ml) promoted the reproduction of T. vaginalis, conversely, in low concentrations (0.5 and 10 ng/ml) respectively; they reduced the reproduction of T. vaginalis. This concentration related effect may not be explained purely by the effect on pH.