Investigation of in vitro effects of estrogens and selective estrogen receptor modulators (serms) on Trichomonas vaginalis


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İnceboz T., Yalcın G., Bayrakal V., Ümit İ., Derici Y.

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, vol.6, no.43, pp.7078-7083, 2012 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 6 Issue: 43
  • Publication Date: 2012
  • Doi Number: 10.5897/ajmr12.920
  • Journal Name: AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH
  • Journal Indexes: CAB Abstracts, Veterinary Science Database
  • Page Numbers: pp.7078-7083
  • Dokuz Eylül University Affiliated: Yes

Abstract

The aim of this study was to investigate if there is a relationship between the hormones and Trichomonas vaginalis growth. A strain of T. vaginalis, was incubated and cultivated to compare the in vitro effects of 17β-Estradiol, Estriol, Raloxifene, Tamoxifen on T. vaginalis trophozoites in terms of different concentrations. High concentrations of 17β-Estradiol and Estriol (20 ng/ml), and Tamoxifen and Raloxifene (100 ng/ml) promoted the reproduction of T. vaginalis, conversely, in low concentrations (0.5 and 10 ng/ml) respectively; they reduced the reproduction of T. vaginalis. This concentration related effect may not be explained purely by the effect on pH.