Investigation of in vitro effects of estrogens and selective estrogen receptor modulators (serms) on Trichomonas vaginalis

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İnceboz T., Yalcın G., Bayrakal V., Ümit İ., Derici Y.

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, cilt.6, sa.43, ss.7078-7083, 2012 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 43
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5897/ajmr12.920
  • Dergi Adı: AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: CAB Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.7078-7083
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate if there is a relationship between the hormones and Trichomonas vaginalis growth. A strain of T. vaginalis, was incubated and cultivated to compare the in vitro effects of 17β-Estradiol, Estriol, Raloxifene, Tamoxifen on T. vaginalis trophozoites in terms of different concentrations. High concentrations of 17β-Estradiol and Estriol (20 ng/ml), and Tamoxifen and Raloxifene (100 ng/ml) promoted the reproduction of T. vaginalis, conversely, in low concentrations (0.5 and 10 ng/ml) respectively; they reduced the reproduction of T. vaginalis. This concentration related effect may not be explained purely by the effect on pH.