Investigation of in vitro effects of estrogens and selective estrogen receptor modulators (serms) on Trichomonas vaginalis


Creative Commons License

İnceboz T., Yalcın G., Bayrakal V., Ümit İ., Derici Y.

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, cilt.6, sa.43, ss.7078-7083, 2012 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 43
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5897/ajmr12.920
  • Dergi Adı: AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: CAB Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.7078-7083
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate if there is a relationship between the hormones and Trichomonas vaginalis growth. A strain of T. vaginalis, was incubated and cultivated to compare the in vitro effects of 17β-Estradiol, Estriol, Raloxifene, Tamoxifen on T. vaginalis trophozoites in terms of different concentrations. High concentrations of 17β-Estradiol and Estriol (20 ng/ml), and Tamoxifen and Raloxifene (100 ng/ml) promoted the reproduction of T. vaginalis, conversely, in low concentrations (0.5 and 10 ng/ml) respectively; they reduced the reproduction of T. vaginalis. This concentration related effect may not be explained purely by the effect on pH.