Effect of PVP formulation on the in vitro photodynamic efficiency of a photosensitizing phthalocyanine
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, vol.23, pp.1587-1591, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 23
- Publication Date: 2019
- Doi Number: 10.1142/s108842461950189x
- Journal Name: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1587-1591
- Keywords: phthalocyanine, photodynamic therapy, polyvinylpyrrolidone, PVP, cancer cells, formulation
- Dokuz Eylül University Affiliated: Yes
Abstract
The administration of photosensitizers and their biocompatibility is crucial to the success of photodynamic therapy treatment. Amongst the various strategies developed to administer photosensitizers of low water-solubility, the use of polyvinylpyrrolidone (PVP), an FDA-approved food additive, is emerging as extremely promising. Its effect on photodynamic outcome was compared to more classical formulation in DMSO and direct solubilization in water. The tetrakis (2-(2-(2-meihoxyethoxy) ethoxy)ethoxy)-Zn(II) phthalocyanine chosen as the model photosensitizer for this study proved to be a powerful photosensitizer. Even if slightly less efficient than DMSO formulation, PVP formulation proved to work very well, with submicromolar IC50 and IC90 values against MDA-MB-231 human cancer cells.