Effect of PVP formulation on the in vitro photodynamic efficiency of a photosensitizing phthalocyanine

Pehlivan E. G., Ek Y., TOPKAYA TAŞKIRAN D., TAZEBAY U. H., DUMOULİN F.

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, vol.23, pp.1587-1591, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23
  • Publication Date: 2019
  • Doi Number: 10.1142/s108842461950189x
  • Journal Name: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1587-1591
  • Keywords: phthalocyanine, photodynamic therapy, polyvinylpyrrolidone, PVP, cancer cells, formulation, SUBSTITUENTS, AGGREGATION, ABSORPTION, COMPLEXES, DELIVERY, THERAPY, TUMORS
  • Dokuz Eylül University Affiliated: Yes

Abstract

The administration of photosensitizers and their biocompatibility is crucial to the success of photodynamic therapy treatment. Amongst the various strategies developed to administer photosensitizers of low water-solubility, the use of polyvinylpyrrolidone (PVP), an FDA-approved food additive, is emerging as extremely promising. Its effect on photodynamic outcome was compared to more classical formulation in DMSO and direct solubilization in water. The tetrakis (2-(2-(2-meihoxyethoxy) ethoxy)ethoxy)-Zn(II) phthalocyanine chosen as the model photosensitizer for this study proved to be a powerful photosensitizer. Even if slightly less efficient than DMSO formulation, PVP formulation proved to work very well, with submicromolar IC50 and IC90 values against MDA-MB-231 human cancer cells.