The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning.

Büyükdeligöz M., Hocaoğlu Aksay N., Oransay K., Tunçok Y., Kalkan Ş.

Balkan medical journal, vol.32, no.3, pp.303-8, 2015 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.5152/balkanmedj.2015.15932
  • Journal Name: Balkan medical journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.303-8
  • Keywords: Adenosine receptor antagonists, citalopram, cardiovascular toxicity, QT prolongation, rat
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning. Our previous experimental study showed that citalopram may be lead to QT prolongation by stimulating adenosine A1 receptors without affecting the release of adenosine.