The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning.

Büyükdeligöz M., Hocaoğlu Aksay N., Oransay K., Tunçok Y., Kalkan Ş.

Balkan medical journal, cilt.32, sa.3, ss.303-8, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/balkanmedj.2015.15932
  • Dergi Adı: Balkan medical journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.303-8
  • Anahtar Kelimeler: Adenosine receptor antagonists, citalopram, cardiovascular toxicity, QT prolongation, rat, SEROTONIN REUPTAKE INHIBITORS, DE-POINTES, HERG, A(2A), DRUGS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning. Our previous experimental study showed that citalopram may be lead to QT prolongation by stimulating adenosine A1 receptors without affecting the release of adenosine.