Experts' opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond

Facchinetti F., Appetecchia M., Aragona C., Bevilacqua A., Espinola M. S. B., Bizzarri M., ...More

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, vol.16, no.3, pp.255-274, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 16 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.1080/17425255.2020.1737675
  • Journal Name: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.255-274
  • Keywords: Myo-inositol (MI), D-chiro-inositol (DCI), alpha-lactalbumin (alpha-LA), insulin resistance, polycystic ovary syndrome (PCOS), non-insulin dependent (type 2) diabetes mellitus (NIDDM), absorption, inositol-resistance, D-CHIRO-INOSITOL, INTERNATIONAL CONSENSUS CONFERENCE, RANDOMIZED CONTROLLED-TRIAL, ACTIVATED RECEPTOR-GAMMA, IN-VITRO FERTILIZATION, DOUBLE-BLIND, CLOMIPHENE CITRATE, ALPHA-LACTALBUMIN, METABOLIC FACTORS, FOLLICULAR-FLUID
  • Dokuz Eylül University Affiliated: No

Abstract

Introduction: This Experts' opinion provides an updated scientific support to gynecologists, obstetricians, endocrinologists, nutritionists, neurologists and general practitioners on the use of Inositols in the therapy of Polycystic Ovary Syndrome (PCOS) and non-insulin dependent (type 2) diabetes mellitus (NIDDM). Areas covered: This paper summarizes the physiology of Myo-Inositol (MI) and D-Chiro-Inositol (DCI), two important molecules present in human organisms, and their therapeutic role, also for treating infertility. Some deep differences between the physiological functions of MI and DCI, as well as their safety and intestinal absorption are discussed. Updates include new evidence on the efficacy exerted in PCOS by the 40:1 MI/DCI ratio, and the innovative approach based on alpha-lactalbumin to overcome the decreased therapeutic efficacy of Inositols in some patients. Expert opinion: The evidence suggests that MI, alone or with DCI in the 40:1 ratio, offers a promising treatment for PCOS and NIDDM. However, additional studies need to evaluate some still unresolved issues, such as the best MI/DCI ratio for treating NIDDM, the potential cost-effectiveness of reduced gonadotropins administration in IVF due to MI treatment, or the benefit of MI supplementation in ovulation induction with clomiphene citrate in PCOS patients.