Urinary Neutrophil Gelatinase-Associated Lipocalin, Cystatin C and Clusterin as Biomarkers for Acute Kidney Injury in Cattle with Tropical Theileriosis


Tümer K. Ç., Polat Dinçer P. F., Babacan S., Yerlikaya Z.

PAKISTAN VETERINARY JOURNAL, cilt.43, sa.2, ss.1-6, 2023 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.29261/pakvetj/2023.02810.29261/pakvetj/2023.028
  • Dergi Adı: PAKISTAN VETERINARY JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1-6
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The emergence of antimicrobial resistance and the emergence of novel pathogens

pose a serious threat to public health and animals around the world. Peppermint

(Mentha piperita) has a variety of therapeutic features, one of which is an

antibacterial property that can be helpful in preventing infections in wildlife. This

property can be found in the extracts of both the stem and the leaf of the plant. In

the current investigation, an extract of Mentha piperita (M. piperita) or clocally

named as peppermint stem and leaf was produced in methanol at a concentration of

70 percent to test its effectiveness as an antibacterial agent against three Gramnegative bacteria. i.e. Escherichia coli (E. coli), Salmonella Typhimurium (S.

Typhimurium) and Pseudomonas aeruginosa (P. aeruginosa) and against one

Gram-positive Bacteria Staphylococcus aureus (S. aureus). Fresh feces and skin

swab samples were taken from wild sheep in the Wildlife Park Gatwala, Faisalabad,

during February 2022. The isolated strains of bacteria were identified and confirmed

microbiologically. Peppermint (stem and leaf) extracts prepared with methanol were

examined for their efficacy against the identified pathogens. The extracts

demonstrated higher inhibitory zones (leaf: 17.5mm, stem:16mm) against S. aureus.

S. Typhimurium, P. aeruginosa and E. coli. The leaf extract showed zones of

inhibition of 16.5, 16, 15.5 and 13mm while stem extract produced zones of

inhibition of 15.5, 14, 16.5, 15mm against S. aureus. S. Typhimurium, P. aeruginosa

and E. coli, respectively. Furthermore, the broth dilution method revealed that the

MIC of peppermint (stem and leaf) was 0.4mg/ml against all tested bacterial strains.

Altogether, these findings indicate that peppermint extracts may be useful in

combating common bacterial infections of wild sheep.