Effect of Nifedipine on Hippocampal Neuron Number in Penicillin-Induced Epileptic Rats


Yilmaz I., Akdogan I., Kaya E., DEMİRCİ G. N.

TURKISH NEUROSURGERY, vol.24, no.2, pp.234-240, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.5137/1019-5149.jtn.8428-13.2
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.234-240
  • Keywords: Penicillin epilepsy model, Nifedipine, Hippocampus, Neuron number, The optical fractionator method, Rat, Epilepsy, Seizure, CALCIUM-CHANNEL INHIBITORS, CEREBELLAR GRANULE NEURONS, RETINAL GANGLION-CELLS, ACID NEUROTOXICITY, MOUSE HIPPOCAMPUS, ANIMAL-MODELS, ANTICONVULSANT, GLUTAMATE, SEIZURES, MICE
  • Dokuz Eylül University Affiliated: Yes

Abstract

AIM: Epileptic seizures lead to neuronal loss in the hippocampus. Experimental epilepsy can be induced by direct application of various chemicals to cerebral cortex. Nifedipine is an L-type voltage-dependent calcium channel blocker. In spite of several studies that show the seizure-suppressing effects of nifedipine, it has been shown that nifedipine does not suppress but conversely increases epileptic seizures. Similarly, contradictory effects of nifedipine have been reported, such as neuroprotection, failed neuroprotection and neurotoxicity. We therefore aimed to investigate the effect of nifedipine on hippocampal neuronal loss in penicillin induced epileptic rats in this study.