Effects of acute footshock stress on antioxidant enzyme activities in the adolescent rat brain

UYSAL HARZADIN N., Acikgoz O., Gonenc S., Kayatekin B. M., Kiray M., Sonmez A., ...More

PHYSIOLOGICAL RESEARCH, vol.54, no.4, pp.437-442, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.33549/physiolres.930632
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.437-442
  • Keywords: footshock stress, dopamine, prefrontal cortex, hippocampus, striatum, superoxide dismutase, PREFRONTAL CORTEX, GLUTATHIONE-PEROXIDASE, SUPEROXIDE-DISMUTASE, INDUCED ENHANCEMENT, LIPID-PEROXIDATION, DOPAMINE, STRIATUM, RELEASE
  • Dokuz Eylül University Affiliated: Yes


In a previous study we demonstrated that acute footshock stress increased glutathione peroxidase activity in the prefrontal cortex and striatum of adult male rats. Adolescents may respond differently to stress as life stressors may be greater than at other ages. The present study examined the effects of the acute footshock stress on superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities and thiobarbituric acid reactive substances (TBARS) levels in adolescent male and female rat brains. We demonstrated that acute footshock stress increased SOD activity in the prefrontal cortex, and increased GPx activity in the hippocampus in female rats. In males, acute footshock stress increased GPx activity in the prefrontal cortex and hippocampus. Footshock stress did not change TBARS levels. These results indicate a strong role of gender in the response of adolescent subjects to various aspects of stress.