Risk factors for a poor hematopoietic stem cell mobilization

DÖNMEZ A., Yilmaz F., Gokmen N., TOMBULOĞLU M.

TRANSFUSION AND APHERESIS SCIENCE, vol.49, no.3, pp.485-488, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.transci.2013.04.040
  • Journal Name: TRANSFUSION AND APHERESIS SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.485-488
  • Keywords: Hematopoietic stem cell mobilization, Poor mobilization, Risk factors, NON-HODGKINS-LYMPHOMA, MULTIPLE-MYELOMA, AUTOLOGOUS TRANSPLANTATION, G-CSF, CHEMOTHERAPY, STRATEGIES, COLLECTION, IMPACT
  • Dokuz Eylül University Affiliated: No

Abstract

Poor mobilization is an important problem in autologous stem cell transplantation. We retrospectively reviewed the data of 165 mobilized patients to identify possible risk factors for a poor stem cell mobilization. 27 patients (16.4%) were categorized as poorly mobilized. The poor mobilization ratio differed according to diagnosis (lymphoma: 25.4%, acute leukemia: 15.4%, amyloidosis: 14.3%, and multiple myeloma: 9.6%). Being diagnosed as lymphoma (odds ratio [OR] = 6.02, p = 0.001), advanced age (OR = 1.05, p = 0.007) and increased weight (OR = 1.03, p = 0.03) were found as possible risk factors. Being diagnosed as lymphoma was shown to be the most important risk factor for a poor mobilization. Leukapheresis staff should be aware of the increased risk of a poor mobilization in lymphoma patients and remobilization methods should be considered from the beginning. (C) 2013 Elsevier Ltd. All rights reserved.