Distribution of interstitial cells of Cajal in the bladders of fetal rats with retinoic acid induced myelomeningocele

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TEKİN A., Karakus O. Z., HAKGÜDER F. G., ATEŞ O., ÖZER E., OLGUNER M., ...More

TURKISH JOURNAL OF UROLOGY, vol.42, no.4, pp.285-289, 2016 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.5152/tud.2016.98474
  • Journal Name: TURKISH JOURNAL OF UROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.285-289
  • Keywords: Bladder contractility, bladder dysfunction, interstitial cells of Cajal, myelomeningocele, neurogenic bladder
  • Open Archive Collection: AVESIS Open Access Collection
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Myelomeningocele (MMC) is one of the most common reason of neurogenic bladder dysfunction in children. Although neurogenic bladder dysfunction occurrence is related with bladder innervation, also there are some changes seen in the smooth muscle and neural cells of the bladder. Interstitial cells of Cajal (ICC) are the pacemaker cells found in organs with peristaltic activity. Although it has been shown that ICC are diminished in the rat urinary bladder with traumatic spinal cord injury, there is no data about ICC in fetal rat bladders with MMC. This study has been conducted to investigate the ICC in the bladders of fetal rats with retinoic acid induced MMC.