The Importance of Apoptosis in Cancer Development and Treatment

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Gokbayrak Atay I. N., Gezer A. H., KASAP E.

TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY, vol.36, no.3, pp.381-388, 2021 (ESCI) identifier

  • Publication Type: Article / Review
  • Volume: 36 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5505/tjo.2021.2574
  • Journal Name: TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE
  • Page Numbers: pp.381-388
  • Keywords: Apoptosis, apoptosis pathways, cancer, cancer development, cancer treatment, DEATH RECEPTOR, C-FLIP, HEPATOCELLULAR-CARCINOMA, BH3-ONLY PROTEINS, BCL-2 FAMILY, IN-VIVO, EXPRESSION, BAX, OVEREXPRESSION, INHIBITOR
  • Dokuz Eylül University Affiliated: Yes

Abstract

Cancer is one of the most important causes of death in our era. Multifactorial causes are involved in the formation of cancer. The reduction of apoptosis is one of these reasons. Failure to activate apoptosis pathways can lead to resistance to the current treatment approaches of cancers. A better understanding of the molecular events that regulate apoptosis in cancers and cancer therapy form the basis of a more rational approach to the development of molecular targeted therapies in the fight against cancer.