Bone mineral density in asthmatic patients using low dose inhaled glucocorticosteroids.

El O., Gulbahar S., Ceylan E., Ergor G., Sahin E., Senocak O., ...More

Journal of investigational allergology & clinical immunology, vol.15, no.1, pp.57-62, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 2005
  • Journal Name: Journal of investigational allergology & clinical immunology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.57-62
  • Keywords: Asthma, Bone mineral density, Inhaled steroid, Osteoporosis
  • Dokuz Eylül University Affiliated: Yes


Inhaled glucocorticosteroids are clearly beneficial in subjects with moderate or severe asthma since they are well tolerated, reduce symptoms, and improve quality of life. Some studies suggest that inhaled glucocorticosteroids can adyersely affect bone mineral density. The aim of this study is to determine the effects of inhaled density was measured from lumbar spine (L1-4) and femur (neck, trochahter and Wara's triangle) by dual energy X-Ray absorptiometry. Age, occupation, menopause and smoking status, alcohol consumption, body mass index, previous fractures, family history of fractures, menstrual history, ooferectomy, number of pregnancies, the duration of lactation, physical activity and calcium intake were questioned according to the European Vertebral Osteoporosis Study Group (EVOS) form. Cumulative inhaled glucocorticosteroid dose was calculated. T score of femoral neck and T score and bone mineral density of Ward's triangle were significantly lower in asthmatic patients compared to control group but no statistically significant correlation was found between the disease duration, inhaled steroid treatment duration, cumulative inhaled dose and annual inhaled steroid dose and bone mineral density measurement. These results suggest that in asthmatic patients using low dose inhaled corticosteroids bone mineral density is lower than in healthy controls but it is still unclear if asthma by itself is a risk factor for osteoporosis. © 2005 Esmon Publicidad.