Expression dynamics of repetitive DNA in early human embryonic development

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Yandim C., KARAKÜLAH G.

BMC GENOMICS, cilt.20, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1186/s12864-019-5803-1
  • Dergi Adı: BMC GENOMICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Repetitive DNA, Human development, Pre-implantation, Single cell RNA sequencing, Repeatome, Bioinformatics, WGCNA, Satellite repeats, DNA methylation, Repeat enrichment, HUMAN PREIMPLANTATION EMBRYOS, ZYGOTIC GENOME ACTIVATION, GENE-EXPRESSION, MOUSE EMBRYOS, RNA, HETEROCHROMATIN, METHYLATION, LANDSCAPE, CHROMATIN, LINEAGE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: The last decade witnessed a number of genome-wide studies on human pre-implantation, which mostly focused on genes and provided only limited information on repeats, excluding the satellites. Considering the fact that repeats constitute a large portion of our genome with reported links to human physiology and disease, a thorough understanding of their spatiotemporal regulation during human embryogenesis will give invaluable clues on chromatin dynamics across time and space. Therefore, we performed a detailed expression analysis of all repetitive DNA elements including the satellites across stages of human pre-implantation and embryonic stem cells.