Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats


Naziroglu M., Karaoglu A., Aksoy A.

TOXICOLOGY, vol.195, no.2-3, pp.221-230, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 195 Issue: 2-3
  • Publication Date: 2004
  • Doi Number: 10.1016/j.tox.2003.10.012
  • Journal Name: TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.221-230
  • Keywords: oxidative stress, cisplatin-nephrotoxicity, lens, liver, selenium, vitamin E, INDUCED NEPHROTOXICITY, LIPID-PEROXIDATION, ANTIOXIDANTS, CHEMOTHERAPY, MECHANISMS, EBSELEN
  • Dokuz Eylül University Affiliated: No

Abstract

Cisplatin is one of the most active cytotoxic agents in the treatment of cancer but its clinical use is associated with nephrotoxicity. Several studies suggest that supplementation with antioxidant can influence cisplatin induced nephrotoxicity. In the present study, we investigated the effect of selenium with high dose vitamin E administration on lipid peroxidation (MDA) and scavenging enzyme activity in kidneys, liver and lens of cisplatin-induced toxicity in rats.