Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats

Naziroglu M., Karaoglu A., Aksoy A.

TOXICOLOGY, cilt.195, sa.2-3, ss.221-230, 2004 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 195 Sayı: 2-3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.tox.2003.10.012
  • Dergi Adı: TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.221-230
  • Anahtar Kelimeler: oxidative stress, cisplatin-nephrotoxicity, lens, liver, selenium, vitamin E, INDUCED NEPHROTOXICITY, LIPID-PEROXIDATION, ANTIOXIDANTS, CHEMOTHERAPY, MECHANISMS, EBSELEN
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Cisplatin is one of the most active cytotoxic agents in the treatment of cancer but its clinical use is associated with nephrotoxicity. Several studies suggest that supplementation with antioxidant can influence cisplatin induced nephrotoxicity. In the present study, we investigated the effect of selenium with high dose vitamin E administration on lipid peroxidation (MDA) and scavenging enzyme activity in kidneys, liver and lens of cisplatin-induced toxicity in rats.