Peritubular Capillaritis in Native Kidney Biopsies

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Sarıoğlu S., Tekin E., Unlu M., Yildiz S., Heybeli C.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, vol.158, no.3, pp.389-394, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 158 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1093/ajcp/aqac061
  • Journal Name: AMERICAN JOURNAL OF CLINICAL PATHOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.389-394
  • Keywords: Peritubular capillaritis, Native kidney biopsy, Glomerulitis, ANTIBODY-MEDIATED REJECTION, PATHOLOGICAL FEATURES, INJURY, GLOMERULONEPHRITIS, CRITERIA
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives To determine the frequency and predictors of peritubular capillaritis (PTCitis) among native kidney biopsies. Methods Consecutive native kidney biopsies of 169 patients were reexamined for capturing possible PTCitis according to the Banff Classification. The relation of PTCitis with demographic and clinicopathological findings was evaluated. Logistic regression analysis was performed to determine predictors of PTCitis. Results Peritubular capillaritis was captured in 90 (53.3%) patients, with scores of 1, 2, and 3 in 57 (33.7%), 31 (18.3%), and 2 (1.2%) patients, respectively. The highest frequency of PTCitis was observed in pauci-immune glomerulonephritis. In univariate analysis, male sex, the presence of interstitial inflammation, pauci-immune glomerulonephritis, and a higher serum creatinine level were associated with a higher risk of PTCitis, while severe interstitial fibrosis/tubular atrophy was associated with a lower risk. The presence of interstitial inflammation (odds ratio [OR], 5.94 [95% confidence interval (CI), 1.41-25.03]; P = .015), pauci-immune glomerulonephritis (OR, 3.08 [95% CI, 1.01-9.36]; P = .048), and a higher serum creatinine level (per 1 mg/dL) (OR, 1.56 [95% CI, 1.14-2.11]; P = .005) were independent predictors of PTCitis development in a multivariate regression model. Conclusions Peritubular capillaritis is common in native biopsies and more likely to be observed in the presence of interstitial inflammation, pauci-immune glomerulonephritis, and a higher serum creatinine level.