Research Information System
TOXICS, vol.13, no.990, pp.2-12, 2025 (SCI-Expanded, Scopus)
This study aimed to assess oxidative DNA damage products in healthcare workers who
are directly exposed to or use ionizing radiation in their work. In the study, three groups
were defined based on the probability of radiation exposure, ranging from the highestrisk
group to the lowest, with the fourth group designated as the control group. First,
a questionnaire was administered to the participants, and then their first morning urine
samples were taken to detect oxidative DNA damage markers. According to the Kruskal-
Wallis test results among the four groups in our study, statistically significant differences
were found only in terms of age, height, and weight (p values = 0.011, 0.038, and 0.003,
respectively). However, it was observed that there was no significant relationship between
the oxidative DNA damage parameters 8-hydroxy-2′-deoxyguanosine (8-OH-dG), and 8,5′-
cyclo-2′-deoxyadenosines (S- and R-cdA) in relation to radiation exposure, with p-values of
0.132, 0.179, and 0.611, respectively. The study’s results revealed that exposure to ionizing
radiation did not cause a significant increase in urinary oxidative DNA damage markers.
This outcome may be associated with the effective use of personal protective equipment
and strict adherence to radiation safety protocols among healthcare workers.