Uracil/tegafur as a possible salvage therapy in chemo-refractory colorectal cancer patients: A single institutional retrospective study
Wspolczesna Onkologia, cilt.19, sa.5, ss.385-390, 2015 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 5
- Basım Tarihi: 2015
- Doi Numarası: 10.5114/wo.2015.53374
- Dergi Adı: Wspolczesna Onkologia
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.385-390
- Anahtar Kelimeler: uracil/tegafur, metastatic colorectal cancer, heavily pretreated, salvage therapy
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Aim of the study: Our aim was to determine the activity and toxicity of uracil/tegafur and leucovorin combination in metastatic colorectal cancer (mCRC) patients who have progressed with all currently active agents. Material and methods: This study was a retrospective analysis of 50 mCRC patients who had previously failed to respond to all available chemotherapeutics and who received subsequent treatment with uracil/tegafur 250 mg/m2 d1-5 in combination with leucovorin 90 mg/day, d1-5 followed by two days' rest. Results: The median age of the patients was 60 years. Most of them (60%) were male. Bevacizumab was used in 65% and cetuximab in 55% of the patients. Thirty-nine patients (78%) were treated with uracil/tegafur in the fourth line setting. The median treatment duration was 4.2 months (range, 2-24 months). The objective response rate and the disease control rate were 4% and 34%, respectively. Median progression-free survival was 4.1 months (95% CI, 3.6-4.6 months) and overall survival was 6.6 months (95% CI, 4.5-8.6 months). Grade 3 or 4 toxicity was seen in 20% (n = 10) of the patients while 60% (n = 6) of them required dose reductions. Conclusions: This retrospective data show that uracil/tegafur may be considered in heavily pretreated mCRC patients because of its activity, lower toxicity, and feasibility.