Alterations of coagulation in metformin intoxication.

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AKINCI B., Yener S., BENGİ G., Yesil S.

Hormones (Athens, Greece), cilt.7, sa.4, ss.325-9, 2008 (Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.14310/horm.2002.1214
  • Dergi Adı: Hormones (Athens, Greece)
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.325-9
  • Anahtar Kelimeler: Anticoagulants, Coagulation, Diabetes mellitus, Metformin overdose, LACTIC-ACIDOSIS, HEMODIALYSIS, ANTIGEN
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery. Our results indicate that both the levels of coagulation proteins synthesized by the liver and the anti-coagulant activity decrease temporarily in metformin intoxication. Nevertheless, no change in the coagulation factors secreted by the endothelium were observed.