Exposure to continuous darkness leads to atypical symptoms of seasonal affective disorder in rats

Isman C. A., Toyran N., Gundogan N. U.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.40, no.2, pp.271-277, 2010 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.3906/sag-0803-26
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.271-277
  • Keywords: Seasonal affective disorder, melatonin, constant darkness, FST, sucrose preference, BEHAVIORAL DESPAIR, MELATONIN, LIGHT, DEPRESSION
  • Dokuz Eylül University Affiliated: No

Abstract

Aim: Prolonged duration of nocturnal melatonin increase has been implicated in the pathogenesis of the seasonal affective disorder (SAD) winter depression. This study was designed to investigate behavioral and physiological consequences of constant dark exposure in male rats for its potential application to human affective disorders.