Reduced power and phase-locking values were accompanied by thalamus, putamen, and hippocampus atrophy in Parkinson's disease with mild cognitive impairment: an event-related oscillation study


Hünerli-Gündüz D., Özbek İşbitiren Y., Uzunlar H., Çavuşoğlu B., Çolakoğlu B. D., ADA E., ...More

Neurobiology of Aging, vol.121, pp.88-106, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 121
  • Publication Date: 2023
  • Doi Number: 10.1016/j.neurobiolaging.2022.10.001
  • Journal Name: Neurobiology of Aging
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Abstracts in Social Gerontology, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Page Numbers: pp.88-106
  • Keywords: Basal ganglia, Event-related, Mild cognitive impairment, Oscillation, Parkinson's disease, Phase, Power, Volumetric MRI
  • Dokuz Eylül University Affiliated: Yes

Abstract

© 2022 Elsevier Inc.Parkinson's disease (PD) is a multifaceted neurodegenerative disorder accompanied by mild cognitive impairment (MCI) as a crucial nonmotor manifestation. Event-related oscillations (EROs) are suggested to reflect cognitive status associated with subcortical structures in neurodegenerative conditions. In this study, 36 individuals with PD-MCI and 32 PD-CN were compared with 60 healthy control (HC) participants using visual EROs by measures of event-related spectral perturbation and inter-trial coherence, along with subcortical gray matter volumes based on the FIRST algorithm. Cross-correlations among electrophysiological, neuropsychological, and structural parameters were investigated exploratively. Both PD-MCI and PD-CN patients had diminished delta and alpha phase-locking than HC, however, electrophysiological abnormalities were more pronounced in PD-MCI over frontal, central, parietal, and temporal locations in almost all frequency bands, accompanied by bilateral thalamus, hippocampus, and right putamen atrophy. PD-CN had lower hippocampal volumes than HC, without exhibiting any subcortical differences from PD-MCI. Lastly, EROs showed low-to-high correlations with structural and neuropsychological measures. These findings may highlight the complex interplay between electrophysiological, neuropsychological, and structural parameters in detected abnormalities of PD-CN and PD-MCI.