Renal tubular P-glycoprotein expression is reduced in plasma cell disorders

Heybeli C., Oktan M. A., ARDA H. Ü., Yildiz S., Unlu M., ÇAVDAR C., ...Daha Fazla

KIDNEY RESEARCH AND CLINICAL PRACTICE, cilt.38, sa.2, ss.186-195, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.23876/j.krcp.18.0134
  • Dergi Adı: KIDNEY RESEARCH AND CLINICAL PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.186-195
  • Anahtar Kelimeler: Amyloidosis, Immunoglobulin light chains, Multipl myeloma, P-glycoprotein, TRANSPORTERS, GENE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: P-glycoprotein (P-gp) transports many chemicals that vary greatly in their structure and function. It is normally expressed in renal proximal tubular cells. We hypothesized that P-gp expression influences light chain excretion. Therefore, we investigated whether renal tubular P-gp expression is altered in patients with plasma cell disorders.