Renal tubular P-glycoprotein expression is reduced in plasma cell disorders

Heybeli C., Oktan M. A., ARDA H. Ü., Yildiz S., Unlu M., ÇAVDAR C., ...More

KIDNEY RESEARCH AND CLINICAL PRACTICE, vol.38, no.2, pp.186-195, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.23876/j.krcp.18.0134
  • Journal Name: KIDNEY RESEARCH AND CLINICAL PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.186-195
  • Keywords: Amyloidosis, Immunoglobulin light chains, Multipl myeloma, P-glycoprotein, TRANSPORTERS, GENE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: P-glycoprotein (P-gp) transports many chemicals that vary greatly in their structure and function. It is normally expressed in renal proximal tubular cells. We hypothesized that P-gp expression influences light chain excretion. Therefore, we investigated whether renal tubular P-gp expression is altered in patients with plasma cell disorders.