Renal tubular P-glycoprotein expression is reduced in plasma cell disorders

Heybeli, CİHAN; Oktan, MEHMET; ARDA, HAYRİ; Yildiz, Serkan; Unlu, Mehtat; ÇAVDAR, CANER; Sifil, Aykut; Celik, All; SARIOĞLU, SÜLEN; Camsari, Taner

doi:10.23876/j.krcp.18.0134

Renal tubular P-glycoprotein expression is reduced in plasma cell disorders

Heybeli C., Oktan M. A., ARDA H. Ü., Yildiz S., Unlu M., ÇAVDAR C., ...Daha Fazla

KIDNEY RESEARCH AND CLINICAL PRACTICE, cilt.38, sa.2, ss.186-195, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 38 Sayı: 2
Basım Tarihi: 2019
Doi Numarası: 10.23876/j.krcp.18.0134
Dergi Adı: KIDNEY RESEARCH AND CLINICAL PRACTICE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.186-195
Anahtar Kelimeler: Amyloidosis, Immunoglobulin light chains, Multipl myeloma, P-glycoprotein
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: P-glycoprotein (P-gp) transports many chemicals that vary greatly in their structure and function. It is normally expressed in renal proximal tubular cells. We hypothesized that P-gp expression influences light chain excretion. Therefore, we investigated whether renal tubular P-gp expression is altered in patients with plasma cell disorders.