Diagnostic Problems in Chronic Basophilic Leukemia

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Cehreli C.

TURKISH JOURNAL OF HEMATOLOGY, vol.35, no.4, pp.283-289, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.4274/tjh.2018.0129
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.283-289
  • Keywords: Myelodysplastic syndrome, Dysplasia, Interleukin-6, Chronic myeloid leukemia, Chronic basophilic leukemia, Mast cell leukemia, DISEASE, CLASSIFICATION, IL-6
  • Dokuz Eylül University Affiliated: Yes


Chronic basophilic leukemia (CBL) is an extremely rare type of leukemia. A literature review revealed six cases reported as primary CBL and five patients with secondary CBL Patients with primary CBL may present with symptoms not related to leukemia. Dysplastic changes in peripheral blood and bone marrow were described and demonstrated in cases of primary and secondary CBL The literature review also revealed that differential counts made by automated blood cell counters may not characterize cells as basophils in patients with primary and secondary CBL and may mislead physicians in making a differential diagnosis. For these reasons, laboratory studies for the diagnosis of CBL are required, including metachromatic staining by toluidine blue and antigen expressions by flow cytometric analysis, to detect the nature of the neoplastic cells as basophils for a reliable diagnosis of CBL. The literature review failed to reveal specific cytogenetic findings in patients with primary and secondary types of CBL.