Akademik Veri Yönetim Sistemi
3. Uluslararası, 28. Ulusal Farmakoloji Kongresi, Antalya, Türkiye, 20 - 23 Kasım 2025, ss.143-144, (Özet Bildiri)
Nephrotoxic Drug Use in Patients with Acute Renal Failure in an Intensive Care Unit: A Retrospective Analysis With MIMIC-III Data Bahar Eryılmaz1 , İbrahim Yıldırım3 , Pembe Keskinoğlu2 , Yeşim Tunçok1 1Department of Medical Pharmacology, Dokuz Eylül University Faculty of Medicine, Izmir 2Department of Biostatistics and Medical Informatics, Dokuz Eylül University Faculty of Medicine, Izmir 3Dokuz Eylül University Faculty of Medicine, Izmir Objective: Acute kidney injury (AKI), one of the global health problems, particularly affects patients in intensive care units. The use of nephrotoxic drugs is a significant cause of AKI cases developing in intensive care units. This study investigated the use of nephrotoxic drugs in patients diagnosed with AKI using the Medical Information Mart for Intensive Care III (MIMIC-III), an openaccess database. Methods: MIMIC-III contains data on vital signs, medications used, laboratory measurements, observation notes, fluid balance, diagnosis codes, and imaging reports for more than 40,000 patients admitted to an intensive care unit in the United States between 2001 and 2012. Data on 3,342 AKI patients were extracted using Structured Query Language and analyzed for use of loop diuretics, vancomycin, amphotericin B, NSAIDs, aminoglycosides, and acyclovir. Statistical analysis used Mann Whitney-U for continuous variables and chi-square for categorical data. To get approval to utilize the dataset, two members of the study team completed the course by NIH. Results: In MIMIC-III, 42.8% of ICU patients with AKI were female, 57.2% male, median age 72 years. Nephrotoxic drugs were used in 82.4% of patients. No statistical difference existed in overall nephrotoxic drug use between patients who died versus survived, including acyclovir use. Aminoglycosides were given to 5.5% of patients who died and 3.6% who survived(p=0.019). Vancomycin was used more in patients who died (68.5% vs 52.1%, p<0.001). Loop diuretics were used less in patients who died (p<0.01). Patients receiving loop diuretics were older with worse renal function, while those receiving acyclovir and aminoglycosides were younger with better renal function (p<0.001). Conclusion: In an open-access ICU database, nephrotoxic medications were commonly used in younger patients with better kidney function. The establishment of anonymized open-access databases will facilitate clinical and pharmacological evaluations and enable similar research to be conducted in our country.This study used data from project TUSEB-A1-42524. Keywords: big data, intensive care, MIMIC-III, nephrotoxic dru