Inhibition of inducible nitric oxide synthase reduces bacterial translocation in a rat model of acute pancreatitis

Simsek I., Refik M., Yasar M., Ozyurt M., Saglamkaya U., Deveci S., ...Daha Fazla

PANCREAS, cilt.23, sa.3, ss.296-301, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 3
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1097/00006676-200110000-00011
  • Dergi Adı: PANCREAS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.296-301
  • Anahtar Kelimeler: acute pancreatitis, nitric oxide, bacterial translocation, inhibitors, ACUTE NECROTIZING PANCREATITIS, EPITHELIAL PERMEABILITY, SMALL-INTESTINE, ENDOTOXIN, INJURY, GUT, PATHOGENESIS, SURVIVAL, SEPSIS
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Introduction: Translocation of bacteria from the gut into pancreatic necrosis is an important factor in the development of septic complications and mortality in acute pancreatitis. S-methylisothiourea (SMT) is an inducible nitric oxide synthase inhibitor that has been shown to decrease bacterial translocation in sepsis and thermal injury.