Inhibition of inducible nitric oxide synthase reduces bacterial translocation in a rat model of acute pancreatitis


Simsek I., Refik M., Yasar M., Ozyurt M., Saglamkaya U., Deveci S., ...More

PANCREAS, vol.23, no.3, pp.296-301, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1097/00006676-200110000-00011
  • Journal Name: PANCREAS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.296-301
  • Keywords: acute pancreatitis, nitric oxide, bacterial translocation, inhibitors, ACUTE NECROTIZING PANCREATITIS, EPITHELIAL PERMEABILITY, SMALL-INTESTINE, ENDOTOXIN, INJURY, GUT, PATHOGENESIS, SURVIVAL, SEPSIS
  • Dokuz Eylül University Affiliated: No

Abstract

Introduction: Translocation of bacteria from the gut into pancreatic necrosis is an important factor in the development of septic complications and mortality in acute pancreatitis. S-methylisothiourea (SMT) is an inducible nitric oxide synthase inhibitor that has been shown to decrease bacterial translocation in sepsis and thermal injury.