RecA: a universal drug target in pathogenic bacteria

Pavlopoulou A.

FRONTIERS IN BIOSCIENCE-LANDMARK, cilt.23, ss.36-42, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2741/4580
  • Dergi Adı: FRONTIERS IN BIOSCIENCE-LANDMARK
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.36-42
  • Anahtar Kelimeler: Bacterial Infections, Antibiotic Resistance, RecA, Drug Targets, DNA-POLYMERASE V, ESCHERICHIA-COLI, HOMOLOGOUS RECOMBINATION, PROTEIN, SOS, RESISTANCE, MECHANISM, PURIFICATION, MUTAGENESIS, COMPLEX
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

The spread of bacterial infectious diseases due to the development of resistance to antibiotic drugs in pathogenic bacteria is an emerging global concern. Therefore, the efficacious management and prevention of bacterial infections are major public health challenges. RecA is a pleiotropic recombinase protein that has been demonstrated to be implicated strongly in the bacterial drug resistance, survival and pathogenicity. In this minireview, RecA's role in the development of antibiotic resistance and its potential as an antimicrobial drug target are discussed.