The Role of the Dopamine beta-hydroxylase Functional Polymorphism in Patients with Early-Onset Parkinson's Disease in the Turkish Population

Erer, Sevda; ERYILMAZ, IŞIL; Colak, Dilara; EGELİ, ÜNAL; ÇEÇENER, GÜLŞAH; TUNCA, BERRİN; Karakus, Ece; Colakoglu, BERRİL; Tokcaer, Ayse; Saka, Esen; Demirkiran, Meltem; Akbostanci, Cenk; ZARİFOĞLU, MEHMET; DOĞU, OKAN; Kaleagasi, Hakan; Kenangil, Gulay; ÇAKMUR, RAİF; ELİBOL, BÜLENT

doi:10.4274/tnd.2020.80633

The Role of the Dopamine beta-hydroxylase Functional Polymorphism in Patients with Early-Onset Parkinson's Disease in the Turkish Population

Erer S., ERYILMAZ I. E., Colak D. K., EGELİ Ü., ÇEÇENER G., TUNCA B., ...More

TURKISH JOURNAL OF NEUROLOGY, vol.27, no.1, pp.21-26, 2021 (ESCI, Scopus, TRDizin)

Publication Type: Article / Article
Volume: 27 Issue: 1
Publication Date: 2021
Doi Number: 10.4274/tnd.2020.80633
Journal Name: TURKISH JOURNAL OF NEUROLOGY
Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
Page Numbers: pp.21-26
Keywords: Early-onset Parkinson's disease, dopamine beta-hydroxylase (DBH), polymorphism, Turkish population
Open Archive Collection: AVESIS Open Access Collection
Dokuz Eylül University Affiliated: Yes

Abstract

Objective: A functional single nucleotide polymorphism, rs1611115, in the dopamine beta-hydroxylase (DBH) gene, is reported to regulate plasma enzyme activity levels. Mere, we report the first evaluation of this association in patients with early-onset Parkinson's disease (EOPD) and healthy controls in the Turkish population.