The relationship between angiotensin converting enzyme gene polymorphism, coronary artery disease, and stent restenosis - Role of angiotensin converting enzyme inhibitors in stent restenosis in patients with diabetes mellitus

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Guneri S., Baris N., Aytekin D., Akdeniz B., Pekel N., Bozdemir V.

INTERNATIONAL HEART JOURNAL, vol.46, no.5, pp.889-897, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.1536/ihj.46.889
  • Journal Name: INTERNATIONAL HEART JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.889-897
  • Keywords: DD genotype, stent restenosis, ACEI treatment, diabetics
  • Open Archive Collection: AVESIS Open Access Collection
  • Dokuz Eylül University Affiliated: Yes

Abstract

Patients with diabetes mellitus (DM) have advanced atherosclerosis compared with nondiabetics. Restenosis after intracoronary stent implantation occurs frequently in diabetic patients. Angiotensin 11 is an important growth factor for the development of neointimil hyperplasia after vascular injury. The aim of our study was to evaluate the relationships between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and coronary artery disease (CAD) and stent restonosis in diabetic patients.