The relationship between angiotensin converting enzyme gene polymorphism, coronary artery disease, and stent restenosis - Role of angiotensin converting enzyme inhibitors in stent restenosis in patients with diabetes mellitus

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Guneri S., Baris N., Aytekin D., Akdeniz B., Pekel N., Bozdemir V.

INTERNATIONAL HEART JOURNAL, cilt.46, sa.5, ss.889-897, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1536/ihj.46.889
  • Dergi Adı: INTERNATIONAL HEART JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.889-897
  • Anahtar Kelimeler: DD genotype, stent restenosis, ACEI treatment, diabetics, INSERTION DELETION POLYMORPHISM, CARDIOVASCULAR EVENTS, ACE-INHIBITORS, DOUBLE-BLIND, DD GENOTYPE, RISK-FACTOR, ANGIOPLASTY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Patients with diabetes mellitus (DM) have advanced atherosclerosis compared with nondiabetics. Restenosis after intracoronary stent implantation occurs frequently in diabetic patients. Angiotensin 11 is an important growth factor for the development of neointimil hyperplasia after vascular injury. The aim of our study was to evaluate the relationships between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and coronary artery disease (CAD) and stent restonosis in diabetic patients.