beta-Tubulin mRNA Expression Profiles During Long-Term Memory Formation in Classically Conditioned C. Elegans

Erdogan M., Sahin E.

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, cilt.30, sa.2, ss.296-304, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2013
  • Dergi Adı: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.296-304
  • Anahtar Kelimeler: C. elegans, learning, memory, long-term memory, classical conditioning, tubulin, NEMATODE CAENORHABDITIS-ELEGANS, GLUTAMATE-RECEPTOR, PROTEIN-SYNTHESIS, APLYSIA, NEURONS, SENSITIZATION, HABITUATION, FACILITATION, CHEMOTAXIS, GENETICS
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

We report on the mRNA expression profiles of beta-tubulin genes in Caenorhabditis elegans during the process of classical conditioning, a type of associative learning. In this research, based on the model that suggests the formation of new synaptic connections for long-term memory storage by means of cytoskeletal rearrangement, we measure the expressional changes on the beta-tubulin mRNA levels via quantitative real-time PCR. Using this method, we find that beta-tubulin mRNA levels do not significantly change in C. elegans during classical conditioning and long-term memory formation process.