Electrochemical Analysis of Liposome-encapsulated Colistimethate Sodium

Kaya H. O., Karpuz M., TOPKAYA ÇETİN S. N.

ELECTROANALYSIS, cilt.34, sa.7, ss.1114-1120, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 7
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/elan.202100570
  • Dergi Adı: ELECTROANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1114-1120
  • Anahtar Kelimeler: Colistimethate sodium, Liposome, Encapsulation, Electrochemical Detection, Differential Pulse Voltammetry, Cyclic Voltammetry
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

In this study, the neutral and cationic liposomal formulations of Colistimethate sodium (CMS), an antibiotic for multi-drug resistant gram-negative bacteria, were prepared and electrochemical quantification of CMS from these liposomes were achieved. This is the first study of the electrochemical detection of CMS released from liposomes. First, the electrochemical properties of CMS were analysed, then the encapsulation efficiency, and the release kinetic of CMS from liposomes were determined with Differential Pulse Voltammetry (DPV) measurements. In addition, Cyclic Voltammetry were applied to determine oxidation signal of CMS. A higher encapsulation efficiency was found in the cationic liposome compared to the neutral liposome. Moreover, CMS was controlled released from liposomes with zero-order drug release kinetics.