EFFECT OF LOCAL TRANEXAMIC ACID ON THE QUALITY OF BONE HEALING IN A RAT SPINAL FUSION MODEL

Şahin E., Berk R. H., Özkal S., Keskinoğlu P., Balcı P., Balcı A.

Spine Surgery and Related Research, cilt.10, sa.2, 2022 (Hakemli Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.22603/ssrr.2021-0113
  • Dergi Adı: Spine Surgery and Related Research
  • Derginin Tarandığı İndeksler: Directory of Open Access Journals
  • Anahtar Kelimeler: Rat, Bone healing, Spinal fusion, Tranexamic acid, Antifibrinolytic, AUGMENTATION, FIBRINOLYSIS, PREVENTION, SURGERY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Introduction: The use of the antifibrinolytic agent tranexamic acid has positive effects on bleeding control, but our knowledge is still limited regarding how fibrinolysis suppression changes the process of bone formation and the quality of bone. Because of the several side effects of systemic tranexamic acid, topical usage has been established in several procedures. This study aimed to investigate the effect of local tranexamic acid on vertebral fusion by using macroscopic, radiologic, and microscopic techniques. We also attempted to determine the safe dose range in case some doses had negative effects on fusion.