The Role of Cytochrome P450 3A5 Enzyme on the Metabolism of Tacrolimus in Rats


Gur O., GÜMÜŞTEKİN M., Murat N., Gidener S.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.1, no.2, pp.53-56, 2017 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 1 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.5152/jbachs.2017.84
  • Journal Name: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.53-56
  • Keywords: AUC, CYP3A5, drug metabolism, rat, tacrolimus, MECHANISM-BASED INACTIVATION, HIV PROTEASE INHIBITORS, P-GLYCOPROTEIN, LIVER-TRANSPLANTATION, BLOOD-CONCENTRATION, PHARMACOKINETICS, MICROSOMES, INDINAVIR, RITONAVIR, POLYMORPHISMS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: The present study was designed to determine the effect ratio of CYP3A5 on the metabolism of tacrolimus that is used as an immunosuppressant for tissue transplantation.