The Role of Cytochrome P450 3A5 Enzyme on the Metabolism of Tacrolimus in Rats

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Gur O., GÜMÜŞTEKİN M., Murat N., Gidener S.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.1, sa.2, ss.53-56, 2017 (ESCI, TRDizin)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 1 Sayı: 2
• Basım Tarihi: 2017
• Doi Numarası: 10.5152/jbachs.2017.84
• Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.53-56
• Anahtar Kelimeler: AUC, CYP3A5, drug metabolism, rat, tacrolimus
• Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: The present study was designed to determine the effect ratio of CYP3A5 on the metabolism of tacrolimus that is used as an immunosuppressant for tissue transplantation.